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Silvestri Cristoforo

Membre chercheur régulier

Professeur adjoint
Université Laval

Thèmes de recherche

Thème 1 - Qualité des aliments

Thème 3 - Alimentation et bien-être

Thème 4 - Personnalisation de la nutrition

Mots clés

microbiome

lipids

metabolism

obesity

endocannabinoid

fats

Coordonnées


  • Université Laval

Professeur adjoint
Faculté de médecine
Département de médecine

Pavillon Ferdinand-Vandry - Local 4211; Centre de recherche de l'Institut de cardiologie et de pneumologie de Québec - Local A3152
1050 avenue de la Médecine
Québec (Québec) G1V 0A6
Canada

2725 chemin Ste-Foy
Québec (Québec) G1V 4G5
Canada

418-656-8711 - poste7229

Liens et réseaux sociaux

Expertises


Les endocannabinoïdes sont des lipides bioactifs qui émettent des signaux par l’intermédiaire de récepteurs cannabinoïdes, qui sont activés par le composant psychoactif de la marijuana : le THC. Le Dr Cristoforo Silvestri se concentre sur l’impact du système endocannabinoïde et des molécules connexes sur le métabolisme et l’obésité, y compris le développement du tissu adipeux, la régulation du métabolisme du glucose et des lipides et la régulation des hormones de modification du métabolisme et des adipokines.

Endocannbinoids are bioactive lipids that signal through cannabinoid receptors, which are activated by the psychoactive component of marijuana: THC. Dr. Cristoforo Silvestri focuses on the impact of the endocannabinoid system and related molecules on metabolism and obesity, including the development of adipose tissue, the regulation of glucose and lipid metabolism, and the regulation of metabolic modifying hormones and adipokines.

Formation


Doctorate - Biology - University of Toronto

Bachelor's Honours - Biology - York University

En savoir plus


Abolghasemi, A., Manca, C., Iannotti, F. A., Shen, M., Leblanc, N., Lacroix, S., Martin, C., Flamand, N., Di Marzo, V., & Silvestri, C. (2021). Investigation into the effects of vitamin D on olanzapine-caused metabolic side effects: Focus on the endocannabinoidome—Gut microbiome axis. International Journal of Molecular Sciences. 2021 Nov, 22(22), 12361e.

Archambault, A.-S., Tinto, F., Dumais, É., Rakotoarivelo, V., Kostrzewa, M., Plante, P.-L., Martin, C., Simard, M., Silvestri, C., Roxane, P., Laviolette, M., Boulet, L.-P., Vitale, R. M., Ligresti, A., Di Marzo, V., & Flamand, N. (2021). Biosynthesis of the novel endogenous 15-lipoxygenase metabolites N-13-hydroxy-octodecadienoyl-ethanolamine and 13-hydroxy-octodecadienoyl-glycerol by human neutrophils and eosinophils. Cells. 2021 Sep 5;10(9):2322

Ayoub, S., Piscitelli, F., Silvestri, C., Limebeer, C. L., Rock, E. M., Smoum, R., Farag, M., de Almeida, H., Sullivan, M., Lacroix, S., Boubertakh, B., Nallabelli, N., Lichtman, A. H., Leri, F., Mechoulam, R., Di Marzo, V., & Parker, L. A. (2021). Spontaneous and naloxone-precipitated withdrawal behaviors from chronic opiates are accompanied by changes in N-Oleoylglycine and N-Oleoylalanine levels in the brain and ameliorated by treatment with these mediators. Frontiers in Pharmacology. 2021 Sep 15;12:706703

Suriano, F., Manca, C., Flamand, N., Depommier, C., Van Hul, M., Delzenne, N. M., Silvestri, C., Cani, P. D., & Di Marzo, V. (2021). Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota. BBA – Molecular and Cell Biology of Lipids. 2022 Jan;1867(1):159056

Manca, C., Lacroix, S., Perusse, F., Flamand, N., Chagnon, Y., Drapeau, V., Tremblay, A., Di Marzo, V., & Silvestri, C. (2021). Oral Capsaicinoid Administration Alters the Plasma Endocannabinoidome and Fecal Microbiota of Reproduction-Aged Women Living with Overweight and Obesity. Biomedicines 2021 Sep 17;9(9):1246; https://doi.org/10.3390/biomedicines9091246

Bertrand, J. A., Woodward, D. F., Sherwood, J. M., Spenlehauer, A., Silvestri, C., Piscitelli, F., Marzo, V. D., Yamazaki, M., Sakimura, K., Inoue, Y., Watanabe, K., & Overby, D. R. (2021). Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 165, 102235. https://doi.org/10.1016/j.plefa.2020.102235

Depommier, C., Vitale, R. M., Iannotti, F. A., Silvestri, C., Flamand, N., Druart, C., Everard, A., Pelicaen, R., Maiter, D., Thissen, J.-P., Loumaye, A., Hermans, M. P., Delzenne, N. M., de Vos, W. M., Di Marzo, V., & Cani, P. D. (2021). Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists. Cells, 10(1), 185. https://doi.org/10.3390/cells10010185

Lefort, C., Roumain, M., Van Hul, M., Rastelli, M., Manco, R., Leclercq, I., Delzenne, N. M., Marzo, V. D., Flamand, N., Luquet, S., Silvestri, C., Muccioli, G. G., & Cani, P. D. (2020). Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism. Cells, 9(5), E1247. https://doi.org/10.3390/cells9051247

Dione, N., Lacroix, S., Taschler, U., Deschênes, T., Abolghasemi, A., Leblanc, N., Di Marzo, V., & Silvestri, C. (2020). Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota. Cells, 9(12), 2705. https://doi.org/10.3390/cells9122705

Manca, C., Boubertakh, B., Leblanc, N., Deschênes, T., Lacroix, S., Martin, C., Houde, A., Veilleux, A., Flamand, N., Muccioli, G. G., Raymond, F., Cani, P. D., Marzo, V. D., & Silvestri, C. (2020). Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling. Journal of Lipid Research, 61(1), 70–85. https://doi.org/10.1194/jlr.RA119000424

Manca, C., Shen, M., Boubertakh, B., Martin, C., Flamand, N., Silvestri, C., & Di Marzo, V. (2020). Alterations of brain endocannabinoidome signaling in germ-free mice. Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids, 1865(12), 158786. https://doi.org/10.1016/j.bbalip.2020.158786

Silvestri, C., Pagano, E., Lacroix, S., Venneri, T., Cristiano, C., Calignano, A., Parisi, O. A., Izzo, A. A., Di Marzo, V., & Borrelli, F. (2020). Fish Oil, Cannabidiol and the Gut Microbiota: An Investigation in a Murine Model of Colitis. Frontiers in Pharmacology, 11. https://doi.org/10.3389/fphar.2020.585096

Di Marzo, V., & Silvestri, C. (2019). Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome. Nutrients, 11(8), 1956. https://doi.org/10.3390/nu11081956 – (review article)

Lacroix, S., Pechereau, F., Leblanc, N., Boubertakh, B., Houde, A., Martin, C., Flamand, N., Silvestri, C., Raymond, F., Marzo, V. D., & Veilleux, A. (2019). Rapid and Concomitant Gut Microbiota and Endocannabinoidome Response to Diet-Induced Obesity in Mice. MSystems, 4(6). https://doi.org/10.1128/mSystems.00407-19

Piscitelli, F., & Silvestri, C. (2019). Role of the endocannabinoidome in human and mouse atherosclerosis. Current Pharmaceutical Design, 25. https://doi.org/10.2174/1381612825666190826162735

Veilleux, A., Di Marzo, V., & Silvestri, C. (2019). The Expanded Endocannabinoid System/Endocannabinoidome as a Potential Target for Treating Diabetes Mellitus. Current Diabetes Reports, 19(11), 117. https://doi.org/10.1007/s11892-019-1248-9

Janssens, A., Silvestri, C., Martella, A., Vanoevelen, J. M., Di Marzo, V., & Voets, T. (2018). Δ9-tetrahydrocannabivarin impairs epithelial calcium transport through inhibition of TRPV5 and TRPV6. Pharmacological Research, 136, 83–89. https://doi.org/10.1016/j.phrs.2018.08.021

Ligresti, A., Silvestri, C., Vitale, R. M., Martos, J., Piscitelli, F., Wang, J., Allarà, M., Carling, R., Luongo, L., Guida, F., Illiano, A., Amoresano, A., Maione, S., Amodeo, P., Woodward, D., Di Marzo, V., & Marino, G. (2018). FAAH-catalyzed C-C bond cleavage of a new multi-target analgesic drug. ACS Chemical Neuroscience. https://doi.org/10.1021/acschemneuro.8b00315

Vitale, R. M., D’Aniello, E., Gorbi, S., Martella, A., Silvestri, C., Giuliani, M. E., Fellous, T., Gentile, A., Carbone, M., Cutignano, A., Grauso, L., Magliozzi, L., Polese, G., D’Aniello, B., Defranoux, F., Felline, S., Terlizzi, A., Calignano, A., Regoli, F., … Mollo, E. (2018). Fishing for Targets of Alien Metabolites: A Novel Peroxisome Proliferator-Activated Receptor (PPAR) Agonist from a Marine Pest. Marine Drugs, 16(11), 431. https://doi.org/10.3390/md16110431

Sentinel North Partner Research Chair on the Gut Microbiome-Endocannabinoid System as an Integrator of Extreme Environmental Influences on Bioenergetics

Associated with the Canada Excellence Research Chair on Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND)