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Animal models

Are you looking for leading-edge expertise to determine the in vivo beneficial effects of your product on obesity, diabetes, cardiovascular diseases, intestinal inflammatory diseases, cognitive disorders or other diseases?

With its many researchers recognized for their expertise and a wide range of animal models, INAF can help you to identify your product's therapeutic potential. 

 

Areas of Expertise

  • Peptides
  • Polyphenols
  • Lipids
  • Probiotics and prebiotics
  • Dairy products
  • Pharmaceuticals

What we offer

In vivo models

  • Rats and mice on a high-fat and high sucrose diet (insulin-resistant obesity)
  • Rats treated with streptozotocin (type 1 diabetes model)
  • LDLrKO/ApoB100 mice (Atherosclerosis, cardiovascular diseases)
  • AMPK KO mice
  • iNOS KO mice
  • A range of genetically obese and insulin-resistant mice and rat models
  • SHR rats (hypertension)
  • Others as needed

Team

Our team is made up of highly qualified, experienced professionals specialized in cell culture and biochemical analysis who work under the supervision of INAF researchers.

Infrastructure and tests available

  • Glucose tolerance and insulin tolerance tests
  • Hyperinsulinemic clamps in rats and mice
  • Weight gain monitoring and energy intake
  • Echocardiography
  • Arterial pressure measurements
  • Measurement of energy expenditure, motor activity and respiratory quotient using a Columbus Oxymax metabolic cage system
  • Analysis of body composition through magnetic resonance imaging using Bruker's minispec system to measure lean tissue, fat and fluid in conscious animals
  • Measurement of blood parameters including glucose, insulin, free fatty acids, triglycerides, cholesterol, adipokines, cytokines and more
  • Measurement of hepatic lipids
  • Others as needed

This platform provides both technical expertise and strategic and scientific support adapted to your needs.