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TIM1: A dynamic simulator of the digestive conditions in the stomach and small intestine

Developed in the Netherlands, the TIM1 model is the most recent and most sophisticated in vitro model in the world. The model is entirely computerized and allows you to independently control a large number of parameters.

TIM- 1 video presentation

Video presenting the options made possible by TIM

Specifications

  • Four sections in a series (stomach, duodenum, jejunum and ileum)
  • pH modulated in the stomach and controlled in the duodenum, jejunum and ileum
  • Gastric emptying movements according to the type of food
  • Peristaltic movements
  • Respected transit time according to the type of food
  • Human body temperature
  • Enzymatic and biliary secretions (pepsin, pancreatin, bile, lipase and trypsin)

Advantages of TIM1 compared to other in vitro models

  • A dynamic system that produces a "meal vs. secretions” ratio varying according to the compartment and time of digestion
  • Water exchange system that simulates the pressure generated by peristaltic movement
  • Contains two semi-permeable membranes that simulate the intestinal absorption of water and digestion products
  • Application of the pH curve in the stomach and gastric release to simulate real digestive conditions
  • The model adapts itself in order to become sterile, with an anaerobic and/or conditions to monitor hydrophobic molecules.

Even more benefits of using the TIM1 service

  • Possibility of developing customized experiments (ex: amino acid dosage, antioxidant dosage, quantification of live bacteria)
  • Good correlation with in vitro tests
  • Easy-to-use (easy sampling in all compartments)
  • Modular conditions: human and animal (monogastric and ruminant)
  • Different ages: child, adult and elderly
  • Pathological conditions: gastric hyperacidity, pancreatic insufficiency, biliary insufficiency, etc.
  • Reproducible results
  • Low-cost compared to testing on animals and humans
  • No ethical constraints

Diagram description:
A. Food entry; B. Peristaltic valves; C. pH metres; D. Enzymes and acid; E. Bile, pancreatin and base; F. Base; G. Pre-filter system; H. Hollow fibre dialysis membrane; I. Entry of electrolytes into the small intestine J. Exiting of absorbed components; K. Efflux.